Australian scientists have found that dysfunction of the lymphatic system of the mesentery, an organ of the human digestive system, can lead to diabetes and obesity. This is reported by the publication Nature Metabolism, Trend reports with reference to Gazeta.ru.
A high-fat diet can stimulate the formation of a network of tortuous and branching lymphatic vessels in the mesentery, experts from the Melbourne Institute of Pharmaceutical Sciences at Monash University said.
The study was organized with colleagues from the University of Melbourne, the University of Auckland and the University of South Australia.
The vessels, called mesenteric vessels, tend to leak lymph fluid, rich in intestinal lipid metabolites and inflammatory mediators, into the visceral adipose tissue of the abdominal cavity. This circumstance causes the accumulation of abdominal fat and leads to insulin resistance.
“In this study, for the first time, we were able to uncover the biological reason why fat accumulation around the abdomen is correlated with higher rates of metabolic diseases such as type 2 diabetes than fat accumulation elsewhere in the body,” said study leader, Associate Professor Natalie Trevaskis.
A high-fat diet has been shown to lead to dysfunction of the mesenteric lymphatic vessels, Trevaskis said. The result can be negative effects on the body such as belly fat and a disorder in which the body produces insulin but does not use it properly.